Matthew 13:57
"And they were offended in him. But Jesus said unto them, A prophet is not without honour, save in his own country, and in his own house."
One of the few places where Jesus' ministry had no effect was in his home city. This is truly sad in that they watched him grow up. They knew something was different about Jesus. They knew that He was not like every other child. His demeanor was different from those with whom He grew up. His desires were different from those with whom He grew up. His life's ambitions were different than any other child that had grown up in that city.